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The Effect and Mechanism of Xiqing Regulating Intestinal Homeostasis on Drug Efficacy of Chronic Kidney Disease

RecruitingPhase 4Ages 18 Years - 75 YearsAllChujin Cao
NCT07182942 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic kidney disease (CKD) has become a major public health problem worldwide. Patients with CKD are often accompanied by azotemia due to impaired renal function and excretion of nitrogen metabolic waste, which leads to multiple organ dysfunction, cardiac dysfunction and other complications. Therefore, it is an important strategy in the treatment of CKD to reduce the burden of kidney in CKD patients by removing nitrogen metabolic wastes in the body. Xiqing, which includes coated aldehyde oxystarch capsules, is a drug with adsorption effect. As an effective nitrogen metabolic waste adsorbent, it is widely used in the treatment of CKD patients. Gut is an important organ for the generation of nitrogen metabolic waste in the body. Intestinal homeostasis is an important regulator of nitrogen metabolism, and supplementation of probiotics is one of the main ways to regulate intestinal homeost

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Written informed consent was obtained; 2. ranging in age from 18 to 75 years; 3. CKD stage 3-5, that is, eGFR \< 60 mL/min/1.73 m2 with non-dialysis stage, no dialysis indication, temporarily stable condition and drug control stage; 4. tolerance of Xiqing and probiotics treatment. Exclusion Criteria: 1. with severe active infection, influence of nutritional status in patients with malignant tumor and other diseases; 2. patients during pregnancy or lactation; 3. unstable vital signs, the condition is not stable, need dialysis patients; 4. patients with intolerance of Xiqing; 5. patients with intolerance of probiotics; 6. taking corticosteroids, antibiotics or other immunosuppressive agents within the past 3 months; 7. taking adsorbent drugs, such as medicinal charcoal tablets, within the past 3 months.
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What it tests

  • Xiqing
  • probiotics
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Where

1 site
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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