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Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals

RecruitingNAAges 18 Years - 40 YearsAllUniversity of Copenhagen
NCT07183488 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively. The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female. * Age between 18-40 years old * BMI between 18.5-29 Exclusion Criteria: * Diabetes * Kidney- or liver disease * Pregnant, lactating or planning to become pregnant within the study period * Supplementation with SCFAs * Supplementation with B12 vitamin * Special dietary habits (e.g. vegan/ketogenic diet) * Ongoing cancer treatment * Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption * Crohn's disease, ulcerative colitis or short bowel syndrome * Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible
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What it tests

  • Propionate followed by Butyrate
  • Butyrate followed by Propionate
  • Propionate followed by Butyrate
  • Butyrate followed by Propionate
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Where

1 site
University of Copenhagen
Copenhagen, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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