๐ฌIn plain words
What the trial is, and whether it could suit you
The goal of this study is to address the significant morbidity associated with preeclampsia diagnosed after delivery. All participants will undergo biomarker evaluation with soluble fms-like tyrosine kinase-1 and placental growth factor (sFlt-1/PlGF) ratio testing before delivery to assess the predictive ability of these biomarkers with new-onset postpartum preeclampsia. High-risk participants will be randomized to a bundle of care strategies aimed at early detection and management of postpartum preeclampsia.
Sign in to get the eligibility rules as simple questions to take to your doctor.
๐ Eligibility rules (as published)
Inclusion Criteria:
* Pregnant patients โฅ 36 weeks gestation without major fetal anomalies
* Age โฅ 18 years
* Admitted for labor at Dhulikhel Hospital, or intend to deliver at Dhulikhel Hospital
* At risk for preeclampsia, using the Clinical Risk Assessment for Preeclampsia according to ACOG and USPSTF
* 1 or more high risk factors:
* History of preeclampsia
* Type 1 or 2 diabetes
* Multifetal gestation?
* Renal disease
* Autoimmune disease
* 2 or more moderate risk factors:
* Nulliparity
* BMI \> 30
* First-degree relative with a history of preeclampsia
* African American race
* Low socioeconomic status
* Age \> 35 years
* History of low birthweight or small for gestational age
* Previous adverse pregnancy outcome
* Interpregnancy interval \> 10 years
Exclusion Criteria:
* Antenatal hypertensive disorder of pregnancy diagnosis, including gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
* Chronic hypertension, according to ACOG guidelines
* Known allergy or contraindication to nifedipine
* Inability or unwillingness to provide informed consent
* Two or more blood pressures with an SBP โฅ140 or DBP โฅ90 after consent and prior to sFlt-1/PlGF testing (screen failure criteria)
๐
What it tests
- Early detection and management of postpartum preeclampsia bundle
Medical College of Wisconsin
Milwaukee, United States
Dhulikhel Hospital
Dhulikhel, Nepal
๐ค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ always decide together with your own doctor.