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Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

RecruitingNAAges 18 Years - anyAllUniversity General Hospital of Patras
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in relation to the appearance of postoperative pulmonary complications (PPCs) in adult patients who are operated and have higher risk of PPCs. The main questions it aims to answer are: * Is MV with lower ΔP better than conventional PMV in preventing PPCs in patients with higher risk for PPCs? * Does MV with lower ΔP decrease hospital stay, Intensive Care Unit (ICU) need and mortality? * Does MV with lower ΔP suit better than PMV to lung characteristics and needs intraoperatively? Researchers will compare MV with the lowest possible Driving Pressure (ΔP) to Protective Mechanical Ventilation (PMV) to see if any of this is more protective than the other concerning PPCs.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria * \>17 years old * Surgery with general anesthesia \& invasive mechanical ventilation * Preoperative ARISCAT score estimation \>25 Exclusion Criteria: * \<18 years old * Preoperative ARISCAT score estimation \<26 * Women during pregnancy or just given birth * Other type of anesthesia (Not general) * Contraindication of administration of neuromuscular blockade agents. * Contraindication of cease of spontaneous ventilation. * Mechanical ventilation without endotracheal intubation. * Severe heart failure / Severe cardiac arrhythmia. * Severe emphysematous lung disease. * Patient denial of participation in the trial.
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What it tests

  • PEEP titration for Minimum Driving Pressure
  • Lung Protective Ventilation
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Where

1 site
University Hospital of Patras
Pátrai, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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