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The Role of DNA and RNA in NGS Analyses for Advaced Stage NSCLC Patients

RecruitingNAAges 18 Years - anyAllIRCCS Azienda Ospedaliero-Universitaria di Bologna
NCT07188480 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with advanced non-small cell lung cancer (NSCLC) usually undergo biopsies to obtain cytological material on which to perform Next Generation Sequencing (NGS) analysis, with the aim of identifying driver gene mutations that may be targeted by specific therapies. With the development of drugs with specific therapeutic targets, the clinical need for re-biopsy or even repeated biopsies is increasing; these biopsies are necessary to identify the mechanisms of drug resistance in the target lesions. Very often, lung cancer presents with small lesions and/or lesions located in areas that are difficult to reach with traditional biopsy techniques. An alternative way to obtain genetic material is to isolate extracellular vesicles (EVs). These are secreted by almost all cell types, transport bioactive molecules, including nucleic acids (RNA and DNA), enclosed in a double lipid layer, and a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years; * Indication for bronchoscopic cytological sampling for further diagnosis of suspected stage IV lung cancer on CT (computed tomography)/PET (positron emission tomography) scans, with consequent need for NGS analysis. * Indication for bronchoscopy in patients with known lung cancer who have already undergone NGS analysis on a cytological-histological sample in the previous five years. * Acquisition of written informed consent. Exclusion Criteria: * Confirmation of small cell lung cancer or other non-NSCLC pathology where there is no indication for NGS testing.
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What it tests

  • bronchial lavage for NGS analysis
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Where

1 site
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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