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IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Angers
NCT07189078 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respiratory distress. The primary objectives of invasive mechanical ventilation are to reduce respiratory effort and improve oxygenation. However, this intervention is also associated with both direct and indirect adverse effects, mainly linked to the need for sedation and often neuromuscular blockade. These include hemodynamic compromise, neuromuscular weakness, ventilator-induced lung injury, and infectious complications. An ideal intubation strategy would therefore strike a balance: avoiding the risks of delayed intubation-such as refractory hypoxemia, excessive respiratory effort, and patient self-inflicted lung injury (P-SILI)-while limiting complications associated with invasive mechanical

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patient * Patient admitted to intensive care less than 24 hours ago * Acute respiratory failure with hypoxemia defined by either: * Oxygen therapy ≥ 10 L/min via high-concentration mask required for 92 ≤ SpO2 ≤ 98% * High-flow oxygen therapy with FiO2 ≥ 50% required for 92 ≤ SpO2 ≤ 98% * Informed consent of the patient or a trusted relative (when the patient is unable to give consent) Exclusion Criteria: * Acute hypercapnic respiratory failure (defined by PaCO2 \> 45 mmHg) * Cardiogenic pulmonary edema * Exacerbation of chronic respiratory disease * Respiratory failure requiring long-term oxygen therapy * Neuromuscular disease * Glasgow Coma Scale score ≤ 12 * Decision to intubate immediately * Invasive mechanical ventilation within the previous 7 days * Treatment limitation decisions for intubation * Person deprived of liberty by judicial or administrative decision : Person undergoing compulsory psychiatric care, person subject to legal protection measures, Pregnant, breastfeeding, or parturient patient
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What it tests

  • Restrictive intubation strategy
  • Liberal intubation strategy
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Where

9 sites
Angers University Hospital, ICU
Angers, France
Le Mans Hospital, ICU
Le Mans, France
Nantes University Hospital, ICU
Nantes, France
Orléans University hospital, ICU
Orléans, France
Pitié-Salpétrière Hospital, Paris University Hospital, ICU
Paris, France
Guadeloupe University Hospital, ICU
Pointe à Pitre, France
Rennes University Hospital, ICU
Rennes, France
Tours University Hospital, ICU
Tours, France

…and 1 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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