๐ฌIn plain words
What the trial is, and whether it could suit you
This study aims to investigate the effects of sustainable diets on traditional and novel cardiometabolic risk factors.
The primary objective is:
โข To test the effects of a sustainable diet on traditional cardiometabolic risk factors, specifically, a metabolic health score.
The secondary objectives are:
* To test the effects of sustainable diets on blood lipids, inflammatory markers, glucose markers, and anthropometric and body composition markers.
* To test the effect of sustainable diets on circulating metabolomic profiles.
* To test the effects of sustainable diets on circulating proteomic profiles.
Participants will receive dietary interventions of a sustainable health diet, namely the PHD diet (Planetary Health Diet), an ovo-lacto-vegetarian diet, or a habitual diet following general recommendations for a healthy diet without advice on consumption of animal products. The three-a
Sign in to get the eligibility rules as simple questions to take to your doctor.
๐ Eligibility rules (as published)
Inclusion Criteria:
* Adults (males and females) between 45 and 70 years of age at the time of inclusion.
* Participants must have at least two metabolic alterations: 1) Waist Circumference (WC) \>102 cm (males) or \>88 cm (females); 2) self-reported medication for blood pressure or blood pressure \>130/85 mmHg; 3) self-reported prediabetes or non-fasting plasma glucose 140-199 mg/dL (prediabetes); 4) self-reported lipid-lowering medication or diagnosis of impaired blood lipids (triglycerides: โฅ 150 mg/dL; and HDL: men: \< 40 mg/dL and women: \< 50 mg/dL).
* Participants are not institutionalized, able to read and provide consent before participation, and willing to attend in-person visits at the study site.
* Participants should have access to a smartphone and computer, or tablet and must be internet-literate.
* Understand Danish both in writing and when spoken.
Exclusion Criteria:
* Participants with any serious illness or history of cancer within the past 5 years (except adequately treated localized basal cell skin cancer or in situ uterine cervical cancer).
* Diagnosed with diabetes mellitus, CVD event (myocardial infarction, revascularization procedure, or stroke), or atrial fibrillation.
* Participants with diagnosed psychiatric conditions or cognitive impairment.
* Current smokers including all kinds of nicotine-containing products.
* BMI \>35 kg/m2.
* Known or suspected abuse of alcohol or recreational drugs. Regular alcohol consumption exceeding the Danish national guidelines (i.e., more than 10 standard drinks per week or more than 4 drinks on any single day) will be excluded.
* Pregnancy or planning a pregnancy in the next year.
* Not willing to consume chicken and fish or not willing to make dietary changes related to the intervention.
* Participants with multiple food allergies that could hinder adherence to the intervention.
* Any other issue that makes the project responsible (PI or medical responsible) doubt the eligibility of the volunteer.