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Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed Interventions

Recruitingn/aAges 23 Weeks - 30 WeeksAllImperial College Healthcare NHS Trust
NCT07191678 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

MAGPIE-2 is a prospective observational study designed to investigate the physiological mechanisms linking blood transfusion and enteral feeding practices to gut perfusion and oxygenation in very preterm infants. The study is nested within the WHEAT International randomised controlled trial, which compares two standard care approaches: withholding versus continuing milk feeds during red blood cell transfusion. While WHEAT evaluates clinical outcomes such as necrotising enterocolitis (NEC), MAGPIE-2 focuses on the underlying physiological changes that may contribute to NEC development. NEC is a serious gastrointestinal condition affecting approximately 10% of extremely preterm infants and is associated with high mortality and long-term neurodevelopmental impairment. Previous observational studies have suggested a temporal link between blood transfusion and NEC onset, particularly when fe

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📋 Eligibility rules (as published)
Inclusion Criteria: * Very preterm babies (born between 23 to \<30 weeks of gestational age ) in the WHEAT International trial * Written informed consent from parents Exclusion Criteria: * Babies who are deemed too unstable to perform the non-invasive monitoring and the ultrasound scan measurements by the attending clinical team * Babies who have already developed Bells stage 2 NEC, had bowel surgery or congenital abdominal conditions such as congenital diaphragmatic hernia, gastroschisis and exomphalos
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What it tests

  • Not listed
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Where

1 site
Queen Charlotte's & Chelsea Hospital, Neontal Unit
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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