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Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System

RecruitingNAAges 18 Years - anyAllJasmin Rettkowski
NCT07193264 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults. The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake. The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Able to give consent. * Healthy adults aged ≥ 18 years. * Regular caffeine consumers (≥1 coffee cup/day or ≥1 energy drink/day) or non-consumers (≤1 cup/month and ≤1 energy drink/month) for at least 6 months. * Willingness to comply with fasting requirements and study procedures. Exclusion Criteria: * Chronic illnesses or medication use affecting metabolism, including metabolic disorders (e.g., diabetes, thyroid dysfunction, metabolic syndrome). * Personal history of cancer. * Personal history of hematological disorders. * History of radiation therapy. * Known caffeine hypersensitivity or intolerance. * Known immunosuppression.
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What it tests

  • Caffeine (200 mg)
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Where

2 sites
ETH GLC
Zurich, Switzerland
ETH GLC
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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