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Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel

RecruitingNAAges 18 Years - 69 YearsAllMadigan Army Medical Center
NCT07199829 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main purpose of this research study is to learn about the effects of supplemental vitamin D3 and vitamin K2 on blood levels and the gut microbial community, called the gut microbiome. There are many influences on blood levels of vitamin D and K to include your dietary intake, lifestyle behaviors (physical activity, sleep), genetic alterations in metabolism of these vitamins, and the gut microbial abundance and diversity. You will be asked to take one capsule containing vitamin D3 (125 mcg), vitamin K2 (180 mcg), a combination of vitamins D3 and K2 (same doses as previous), or a placebo powder for 90 days. You will also be asked to complete questionnaires, undergo body composition and blood pressure measurements, provide blood samples and a stool swab, all on 2 occasions about 3 - 4 months apart. By conducting this study, we aim to identify the frequency of common genetic alterations

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * able to read and understand English * 25 OHD serum level equal to or less than 30 ng/mL * willing to discontinue vitamin D3 and/or K2 supplements for 4.5 months * military beneficiary (Active Duty, Retired, Dependent) * remaining employed at workplace for 6 months Exclusion Criteria: * Diagnosed medical condition that prevents nutrient absorption from food (e.g. Inflammatory Bowel Disease, Celiac Disease, post-Roux-en-Y/Gastric sleeve surgery) * Pregnant or breastfeeding * Current antibiotic use or within past 3 months * Current anticoagulant use or within past 3 months * Current weight loss or fat malabsorption medication use (e.g. Glucagon-Like Peptide 1 agonists, Orlistat) * Allergies or sensitivities to methylcellulose, vitamin D (D3, D2), or vitamin K (K2, Menaquinone-4, Menaquinone-7)
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What it tests

  • Vitamin Arm 1
  • Vitamin Arm 2
  • Vitamin Arm 3
  • Placebo
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Where

1 site
Madigan Army Medical Center
Tacoma, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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