Impact of Internal Menstrual Protections on Immunity and Vaginal Microbiota

Inclusion Criteria: * Willingness to comply with all study procedures and availability for the duration of the study. * Female, aged 18 to 49 years. * In general good health, as determined by medical history. * Covered by the national health insurance system. * Willing to sign a written informed consent form. * Has already experienced menstruation prior to the start of the study. * No vaginal sexual intercourse within 72 hours before the study visit. * Has had at least 6 menstrual periods in the past 12 months. Exclusion Criteria: * HIV infection. * Positive diagnosis for chlamydia or syphilis at screening or within 4 weeks prior to screening. * History of hormonal disorders or menstrual cycle irregularities. * Metrorrhagia. * Pregnancy or breastfeeding. * Family members or close relatives of the clinical or scientific team. * Treatment with any medication for chronic inflammatory disease or chronic conditions (e.g., cancer, arthritis, transplantation) within the past 12 months. * Participation in an ongoing clinical trial. * Receiving or having received antibiotic treatment within the 4 weeks prior to the study. * Refusal to be informed in case of detected abnormalities. * Indistinct use of both tampons and menstrual cups. * Never having had vaginal penetrative intercourse.