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Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery

RecruitingPhase 3Ages 18 Years - anyAllNegovsky Reanimatology Research Institute
NCT07200180 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting. These interventions have proven effective in preventing ischemic stroke in patients with hemodynamically significant carotid artery stenoses. However, even following a technically successful procedure, the risk of perioperative ischemic brain injury persists. According to meta-analyses, one in five patients exhibits covert ("silent") strokes after reconstructive interventions, with their frequency being ten times higher than that of clinically manifest events. Such lesions are associated with cognitive decline and an increased risk of dementia. An additional risk factor is the "no-reflow" phenomenon-an impairment of microcirculatory reperfusion that occurs even after the restoration of macrovascular blood flow, thereby limitin

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * age \> 18 years * elective carotid artery surgery * general anesthesia * written informed consent Exclusion Criteria: * The presence of any mental disorder according to the International Classification of Diseases 10th Revision which is confirmed by a psychiatrist. * The presence of any neuromuscular disease according to the International Classification of Diseases 10th Revision * Heart failure equal 3 or 4 class according to the New York Heart Association Functional Classification * Pregnant or breast-feeding women * Inability to undergo a preoperative assessment for any reason * Previously enrolled in this trial
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What it tests

  • ะrgon-oxygen breathing mixture
  • Nitrogen-oxygen breathing mixture
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Where

2 sites
GBWZ of Moscow city hospital n.a. S.P. Botkin
Moscow, Russia
Demikhov Municipal Clinical Hospital 68
Moscow, Russia
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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