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Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI

Recruitingn/aAges 18 Years - anyAllClinical Hospital Center Rijeka
NCT07201363 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prediction of conduction disorders (CDs) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is an important and complex process with a significant impact on patient outcomes. The goal of this observational prospective trial is to investigate the role of pre-procedural values of systemic biomarkers of inflammation and fibrosis in the prediction of new-onset CDs and permanent pacemaker implantation (PPI) in patients undergoing the TAVI procedure.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written consent to participate in the trial * Diagnosis of severe AS according to current European Society of Cardiology (ESC) guidelines for valvular heart disease Exclusion Criteria: * Acute infectious disease * Chronic inflammatory or autoimmune disease * Corticosteroid or other immunosuppressive therapy * Active malignant disease * Liver disease accompanied by dysfunction * Permanent pacemaker implanted previously * An acute myocardial infarction within three months before the procedure * A surgical procedure within three months before the procedure * Previous surgical or transcatheter aortic valve replacement/implantation * End-stage chronic kidney disease (eGFR \<15 ml/min)
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What it tests

  • Biomarkers of inflammation and fibrosis in pre-procedural serum blood samples
  • Transthoracic echocardiography with myocardial deformation analysis and staging according to the extent of cardiac damage related to AS
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Where

1 site
Clinical Hospital Center Rijeka
Rijeka, Croatia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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