💬In plain words
What the trial is, and whether it could suit you
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging. It leverages advanced multiparametric brain and spinal cord imaging at high (3T) and ultra-high magnetic fields (7T) to assess structural, functional, metabolic, and mesoscale changes in the central nervous system (CNS). Particular emphasis is placed on sodium (23Na-MRI) and phosphorus (31P-MRI) imaging, along with layer-dependent brain connectivity analysis.
The primary objective is to evaluate the impact of neuronal energy failure, measured via sodium concentration, on functional and structural reorganization in both healthy individuals and patients with various neurological conditions. Directed brain network models will be constructed from MRI data to quantify the connectivity strength (in- and out-degre
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Age:Female or male, aged 18 years or older.
* Health Status: No uncontrolled general diseases, such as cancer, autoimmune diseases, liver failure, severe or untreated high blood pressure, or severe rhythm disorders. No chronic psychiatric illnesses, including severe dementia.
* MRI Compatibility: No contraindications for MRI exams (e.g., claustrophobia, metal foreign bodies, pacemakers, severe kidney failure).
* Social Security Coverage: Participants must have social security coverage.
* Informed Consent: The participant must have read, understood, and signed the informed consent after being adequately informed about the study.
* Specific Disease Criteria (For Disease Groups): Specific inclusion criteria apply to each pathology, such as MS (based on McDonald criteria), NMOSD (Wingerchuk 2015), Alzheimer's (meeting NINCDS-ADRDA criteria), etc.
Exclusion Criteria:
* Pregnancy: Pregnant women are excluded from the study.
* Inability to Provide Informed Consent:
* Any participant who refuses to sign the informed consent or is unable to do so due to mental or physical conditions.
* Refusal of MRI: Individuals who refuse to undergo brain MRI.
* Contraindications for MRI:Participants with contraindications for MRI exams, such as claustrophobia, metal foreign bodies, pacemakers, or severe kidney failure.
* Medical Conditions: Known allergy to Dotarem (contrast agent) for neuroinflammatory patients. Individuals with severe renal insufficiency or other conditions that prevent MRI scanning.
Cognitive or Psychiatric Issues:
Chronic psychiatric conditions, including severe dementia or cognitive dysfunction that could hinder participation.
Legal or Institutional Restrictions:
Adults under legal protection (e.g., under guardianship or curatorship). Individuals deprived of their liberty.
Other Medical Conditions:
Individuals with neurological diseases such as ischemic accidents, brain trauma, or encephalitis.
Patients on treatments that would interfere with the study, as outlined for each disease.
Allergy to Contrast Agent:
Allergy to Dotarem for neuroinflammatory patients (MS, NMOSD, etc.).
Inability to Adhere to Protocol:
Participants who are unable or unwilling to comply with the study protocol.
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