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Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders

Recruitingn/aAges 70 Years - anyAllUniversity Hospital, Rouen
NCT07205003 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The mechanical behavior of conductance arteries is viscoelastic. While the elastic component has been extensively studied, the viscous component has often been neglected for methodological reasons and also because it was considered weak. Unlike a purely elastic solid, which exhibits instantaneous deformation/relaxation upon application/discontinuation of a force, a viscoelastic solid is characterized, from a mechanical point of view, by a delay between the application or discontinuation of the force and deformation. Thus, at the arterial level, the elasticity of the arterial wall allows the internal diameter to increase proportionally to the blood pressure during systole. The viscous component will induce a delay in diameter restoration, resulting in a larger diameter at each pressure level during the diastolic phase compared to the systolic phase. This results in a shift between the sy

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age over 70 * Memory consultation consultant (neurology or geriatrics) * Brain MRI less than one year old or planned as part of the cognitive assessment performed. * Patient diagnosed with Alzheimer's disease according to DSM-5 criteria or vascular dementia according to DSM-5 criteria, or presenting a memory complaint without evidence of a dementia-related condition. * No objection from the patient or their caregiver. * Patient covered by a health insurance plan Exclusion Criteria: * Known unilateral or bilateral carotid stenosis or history of carotid surgery * Permanent CA/AF * Patient presenting with confusion * Known psychiatric illness (severe depression, psychosis, etc.) * Non-vascular, non-Alzheimer's dementia (e.g., Lewy Body Dementia, Parkinsonian Dementia, Progressive Supranuclear Palsy) * Refusal to participate * MMS less than or equal to 10 * Contraindication to performing an MRI * Any acute decompensated pathology * Patient under guardianship or curatorship
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What it tests

  • Assessment of carotid wall viscosity in patients with vascular dementia
  • Assessment of carotid wall viscosity in patients with Alzheimer's disease
  • Assessment of carotid wall viscosity in patients not presenting dementia.
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Where

1 site
University Rouen Hospital
Rouen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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