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The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome

RecruitingNAAges 1 Year - 16 YearsAllAin Shams University
NCT07206537 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Long-term glucocorticoids therapy is associated with various complications, including decreased bone strength (Glucocorticoid-induced osteoporosis) and an increased risk of fracture. Vitamin K2 has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism. This study examines the impact of oral vitamin K2 supplementation on bone metabolism in pediatric patients with nephrotic syndrome on long-term steroid therapy, offering valuable therapeutic insights

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📋 Eligibility rules (as published)
Inclusion Criteria: * Nephrotic patients under 16 years of age of both genders who were treated with GC for the first time. GC treatment was initiated at a dose of 2 mg/kg/day prednisolone with gradual dose reduction. * All patients have been on glucocorticoid therapy for more than 6 months. All patients have sufficient vitamin D level 30 ng/ml (75 nmol/L) or above. Exclusion Criteria: 1. Patients with impaired kidney functions. 2. Non-compliant patients on medications or vitamin supplements. 3. Diseases that affect fat-soluable vitamins absorption such as gallbladder or biliary disease, cystic fibrosis, celiac disease, etc. 4. History of vitamin K-related disorders as bleeding disorders, osteomalacia , etc. 5. History of bone fracture before the study. 6. Any nephrotic syndrome with identified genetic causes.
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What it tests

  • Vitamin K 2
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Where

1 site
Ain Shams University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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