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Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures

RecruitingPhase 2Ages 18 Years - 40 YearsAllNishtar Medical University
NCT07208799 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The rationale of the current research is to address the limitation of existing knowledge as it is not clear which of the two drugs (Dexamethasone or Methylprednisolone) is more effective in reduction of postoperative sequelae in patient with mandibular parasymphysis fracture. This study fills the gap by providing sound evidence on the preferred steroid option to help clinicians have more data to make decisions and improve patients' health. The result of this research will then be added to the evidence-based protocols for the treatment of parasymphysis fractures.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients aged 18 to 40. 2. Both Gender. 3. Fracture less than a week old. 4. Isolated mandibular parasymphysis fractures. Exclusion Criteria: * 1\. Immunocompromised patients (due to increased risk of infection and complications). 2\. Patients experiencing acute pain from conditions such as pulpitis, abscesses, or other acute infections (to ensure that acute pain does not confound the study results). 3\. Patients reporting hypersensitivity to steroids (to avoid adverse reactions). 4\. Patients taking or requiring prophylactic antibiotics or anti-inflammatory drugs before surgery (to prevent confounding effects on study outcomes). 5\. Patients with a history of systemic steroid administration for 15 days (as this could affect the study's outcomes). 6\. Patients with chronic pain problems or mental disorders (to maintain consistency in response to treatment). 7\. Patients with comminuted fractures (to maintain consistency in fracture type). 8\. Pregnant or lactating women (to avoid potential risks to the fetus and nursing infant). 9\. Smokers who smoke at least 10 cigarettes per day for 2 years (to minimize the impact of smoking on healing and recovery). ria:
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What it tests

  • Dexamethasone
  • Methylprednisolone (Corticosteroid)
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Where

1 site
Nishtar Institute of Dentistry Multan
Multan, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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