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Fructose Intestinal Gluconeogenesis

RecruitingNAAges 20 Years - 55 YearsAllTouro University, California
NCT07209202 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will test the hypothesis that within a defined range of fructose intake, the ability to convert fructose to glucose (via gluconeogenesis) in the small intestine plays a protective role for the liver, shielding it from the deleterious effects of fructose. We will investigate whether this protective effect of the intestine is impaired in individuals with obesity.

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📋 Eligibility rules (as published)
Inclusion Criteria: * BMI 30 to 38 kg/m2 (obese group) or BMI 19 to 25 kg/m2 (lean group) Exclusion Criteria: * Pregnancy or lactation within the past six months; * Type 1 or 2 diabetes mellitus (including fasting glucose ≥126 mg/dL, HgbA1c ≥6.5%); * History of liver disease or AST and ALT 2x above the upper limit of normal; * Fasting triglyceride \> 300 mg/dl; total cholesterol levels above the 95th percentile for age and sex; * Hemoglobin (Hgb) \<12.5g/d or hematocrit\<3x Hgb value; * Report of HIV or hepatitis B or C infection; * History of cancer, other than basal cell or squamous cell carcinoma or kidney disease stage 3 or higher or patients currently on dialysis; * Use of any anti-diabetic medications or hypolipidemic agents in the past six months; * History of surgical procedure for obesity; * Change in body weight \>5% in the past six months (by self-report); * History of other conditions known to affect insulin sensitivity and lipid metabolism (e.g., polycystic ovary syndrome), history of galactosemia, hereditary fructose intolerance, or who test positive for fructose malabsorption at screening; * Known intolerance to acetaminophen.
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What it tests

  • High fructose meal
  • Low fructose meal
  • 13C labeled fructose, oral
  • 13C labeled fructose, intravenous
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Where

1 site
Touro University California
Vallejo, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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