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Evaluation of Regenerative Endodontic Treatment for Immature Teeth

RecruitingNAAges 9 Years - 15 YearsAllKafrelsheikh University
NCT07210359 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment using RetroMTA in patients aged 9 to 15 years. The main questions it aims to answer are: Does the use of DDM improve clinical and radiographic outcomes such as root length, dentinal wall thickness, and apex closure? Is DDM a viable bioactive alternative to RetroMTA as a coronal sealing material in regenerative endodontic procedures? Researchers will compare three groups: one using RetroMTA, one using a DDM-TheraCal LC mixture, and one using TDM-Hydrogel, to see if these materials differ in their effects on regenerative outcomes. Participants will: Undergo two treatment visits including canal disinfection, induction of bleeding to form a blood clot scaffold,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Systemically healthy patients (i.e., free of any systemic diseases). * Patients presenting with immature permanent single-rooted teeth. * Age: 9 -15 years. * Teeth diagnosed as either vital (asymptomatic irreversible pulpitis or symptomatic irreversible pulpitis and the bleeding didn't stop after 5 minutes application of hemostatic agent) or non-vital pulp. Exclusion Criteria: * Patients who are allergic to any drugs used in this study or with systemic illness * Teeth that are grossly decayed or fractured and require post and core as final restorations * Presence of periodontal pockets greater than 4 mm. * Radiographical evidence of apical foramen less than 1 mm. * Presence of periapical radiolucency exceeding 10 mm. * Presence of external or internal root resorption. * Patients with a history of major surgeries like cardiac, kidney transplantation, haemodialysis.
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What it tests

  • human treated dentin matrix hydrogel
  • Theracal LC - Demineralized dentin matrix combination
  • Retro Mta
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Where

1 site
KafrelsheikhU
Kafr ash Shaykh, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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