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Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria/Host Interaction (DAIRY-SHAPE)

Recruitingn/aAges 18 Years - 60 YearsAllInstitut National de Recherche pour l'Agriculture…
NCT07212400 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The gut microbiota plays a crucial role in health through its involvement in pathogen defense, immune regulation, and nutrient digestion. Microbiota diversity is essential to maintain these functions, and disturbances caused by antibiotic intake or extreme diets can lead to an imbalance (dysbiosis), which is often described as being implicated in numerous diseases as well as in the proliferation of antibiotic-resistant pathogens. The microbiota is defined as the community of microorganisms inhabiting the intestine, including bacteria, viruses, and bacteriophages (phages). These phages, through their ability to destroy the bacteria they infect, play an important role in regulating bacterial populations and could therefore be essential for restoring balance and diversity in the gut. Probiotics, foods that support the microbiota such as dairy products, are of particular interest because t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years and ≤ 60 years * Varied and balanced omnivorous diet Exclusion Criteria: * Vegetarian, vegan, or restrictive diet * Use of medications (antibiotics, anti-inflammatory drugs, immunosuppressants, and/or probiotics, prebiotics, or synbiotics), either as drugs or dietary supplements, within the 3 months prior to sample collection * Pregnant and/or breastfeeding women * Presence of an acute or chronic disease (gastrointestinal, metabolic, immune, or inflammatory), diagnosed or suspected * Colonoscopy within the past 3 months * Known food allergy or intolerance (e.g., gluten, lactose, FODMAPs) that may alter the usual diet and/or microbiota composition * Individuals under legal protection (guardianship, trusteeship, etc.)
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What it tests

  • Not listed
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Where

1 site
Metagenopolis
Jouy-en-Josas, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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