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High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy

RecruitingPhase 2, Phase 3Ages 18 Years - anyAllCopenhagen University Hospital, Rigshospitalet
NCT07213375 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 year * Able to understand written and spoken Danish language * PCS ≥20 * Signed written informed consent form. * Patient planned to elective VATS lobectomy/segmentectomy Exclusion Criteria: * Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids. * Individuals with diabetes requiring insulin treatment. * Pregnant or breastfeeding patients. * Patients with known allergies to the study drug. * Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection. * Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and/or antidepressant medications. * Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders. * Regular users of opioid medications. * Patients requiring reoperation within the first two postoperative days. * Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my/segmentectomy.
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What it tests

  • Dexamethasone
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Where

1 site
Department for Cardiothoracic Surgery, Rigshospitalet
Copenhagen, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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