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The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

Recruitingn/aAges 18 Years - anyAllBrigham and Women's Hospital
NCT07222683 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured by a positron emission tomography (PET) scan using a marker called myocardial flow reserve (MFR). In CKD, ongoing inflammation and abnormal blood vessel growth can damage these small vessels, leading to heart stiffness and weaker heart function. A kidney transplant offers a unique chance to study how better kidney function and reduced inflammation affect heart health. The observational RESTORE study ("Impact of Renal Transplant on Coronary Microvascular Function in Patients with Advanced CKD") will measure heart blood flow and function before and after transplant. The study will test whether

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📋 Eligibility rules (as published)
Inclusion Criteria: * Renal transplant candidate on the waitlist * Age greater or equal to 45 years, or if 18-44 years of age on dialysis for 5 years or more Exclusion Criteria: * Left ventricular ejection fraction (LVEF) \< 40% * History of coronary artery bypass grafting (CABG) * History of heart transplant * Patients who undergo revascularization as a result of pre-transplant cardiac PET
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What it tests

  • Not listed
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Where

1 site
Brigham and Women's Hospital
Boston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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