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Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma

Recruitingn/aAges 18 Years - anyAllJohn Kirkwood
NCT07223411 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This translational study will examine the immune effector responses of patients who received a two-drug combination for first line therapy by examining tumor and peripheral blood of participants with unresectable locally advanced or metastatic melanoma.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Study participants who meet inclusion criteria for the HCC 24-056 study will be eligible for this study. 2. Participants must be willing to provide additional samples beyond what is required of them in HCC 24-056. These include: 1. 3 additional tumor biopsies 2. 3 additional blood draws 3. Participants must have biopsiable non-target disease amenable to at least 3 biopsies. 4. Must have the ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: 1\. Study participants who do not qualify to enroll in the HCC 24-056 study will not be eligible for this study. \-
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What it tests

  • Fianlimab + Cemiplimab
  • Relatlimab + Nivolumab
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Where

1 site
UPMC Hillman Cancer Center
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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