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โ† Trials
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Impact of Intraoperative Oxygenation Practices on Patient Outcomes

RecruitingNAAges 18 Years - anyAllFrederic T Billings IV
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In plain words

What the trial is, and whether it could suit you

This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiOโ‚‚ 0.21-0.40), intermediate (FiOโ‚‚ 0.40-0.80), and higher (FiOโ‚‚ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patient located in a participating operating room * Planned surgery includes tracheal intubation Exclusion Criteria: * Patient is known to be less than 18 years old * Patient is known to be pregnant * Patient is known to be a prisoner. * Patient is American Society of Anesthesiologists (ASA) classification-6 (i.e., organ donor) * Patient's planned surgical case includes open heart surgery, defined as surgery on the heart or ascending aorta requiring sternotomy or thoracotomy. * Patient's planned procedure requires prolonged apnea, bronchoscopy, airway surgery, or one-lung ventilation. * Patient's planned surgical case includes use of extracorporeal membrane oxygenation (ECMO). * Patient is known to have a history of bleomycin treatment. * Patient was enrolled in the trial in the prior 30 days.
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What it tests

  • Lower FiO2
  • Intermediate FiO2
  • Higher FiO2
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Where

4 sites
University of Michigan Hospital
Ann Arbor, United States
Nebraska Medical Center
Omaha, United States
Vanderbilt University Medical Center
Nashville, United States
University of Utah Huntsman Cancer Institute
Salt Lake City, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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