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Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer

Recruitingn/aAges 18 Years - anyAllCity of Hope Medical Center
NCT07226154 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to develop and validate a predictive microRNA (miRNA) panel to assess the response to neoadjuvant chemotherapy (NACT) in patients with resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically confirmed pancreatic ductal adenocarcinoma (PDAC). * Underwent neoadjuvant chemotherapy (FOLFIRINOX or Gemcitabine/nab-paclitaxel). * Availability of pre-treatment plasma samples. * Underwent curative-intent resection (R0 or R1). Exclusion Criteria: * Inadequate plasma samples or poor RNA quality for exosomal miRNA analysis. * Non-adenocarcinoma histology. * Presence of synchronous or multiple primary malignancies. * Receipt of chemotherapy regimens other than standard FOLFIRINOX or gemcitabine plus nab-paclitaxel (GEM-NABP). * Presence of active inflammatory or autoimmune diseases.
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What it tests

  • Small RNA sequencing
  • PRECEPT assay (qRT-PCR validation)
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Where

1 site
City of Hope Medical Center
Duarte, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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