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← Trials
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Endothelial Dysfunction After SCI

Recruitingn/aAges 18 Years - anyAllCraig Hospital
NCT07227727 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.

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📋 Eligibility rules (as published)
SCI Inclusion Criteria * Over age 18 years * Chronic (\>12 months) SCI * Motor complete (AIS A/B) SCI * Paraplegia (neurological level of injury \[NLI\] at T2 or below) Non-injured Inclusion Criteria • Over age 18 years Exclusion Criteria (Both SCI and Non-injured) * Overt chronic diseases as assessed by: a) clinically documented medical history; b) physical examination; c) blood pressure and ECG at rest; and d) complete blood chemistries and hematological evaluation. * Active infection * Recent (\< 3 months) surgery * Current smoking history (within past 12 months) * Report more than low-risk alcohol consumption * History of drug abuse * Currently taking cardiovascular (statins, beta-blockers) therapeutics and/or other medications that could influence the outcome measures
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What it tests

  • Intra-arterial Infusion of Vasoactive Agents
  • Intra-arterial Vitamin C Infusion
  • Blood Sampling
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Where

1 site
Craig Hospital
Englewood, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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