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Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury

Recruitingn/aAges 18 Years - 89 YearsMaleCraig Hospital
NCT07227740 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly understood. The investigators aim to uncover why this happens and find ways to prevent it. Our research focuses on how important cells which line blood vessels, called endothelial cells, function after SCI. The investigators test endothelial function in live conscious people with SCI. The investigators also study signaling molecules endothelial cells release called endothelial cell derived microvesicles (EMVs), which the investigators can measure in blood to tell us the health of endothelial cells. By using these rigorous tests of vascular function, the investigators have determined that endothelia

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📋 Eligibility rules (as published)
Inclusion Criteria: * Between ages 18-89 years of age * Male Sex * History of motor complete (AIS A/B) paraplegia (NLI T3 or Below) * Time since injury \<6 months at time of enrollment (Subacute injury) * Testosterone Deficiency defined as \< 300ng/dL Exclusion Criteria: * Overt cardiovascular disease assessed by a) medical history, b) physical examination c) electrocardiogram * Anaphylaxis to betadine, lidocaine, iodine * Active infection at time of enrollment. * Recent surgery (\<1 month) at time of enrollment. * History smoking tobacco (currently or in the past 12 months) * History of more than low-risk history of alcohol consumption * History of drug abuse * History of use of cardiovascular-acting (i.e. statins, beta-blockers) therapeutics * History of other health habits, medications, and supplements that could influence the outcome measures deemed by principal investigators and investigative team.
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What it tests

  • Intra-arterial Infusion of Vasoactive Agents
  • Intra-arterial Vitamin C Infusion
  • Blood Sampling
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Where

1 site
Craig Hospital
Englewood, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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