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Effect of High-Intensity Transcranial Alternating Current Stimulation on Gambling Disorder: A Randomized Controlled Trial

RecruitingNAAges 18 Years - 60 YearsAllShanghai Mental Health Center
NCT07228182 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators assume that High-intensity transcranial Alternating Current Stimulation (HI-tACS) could improve gambling disorder patients' executive-control function by modulating abnormal neural activity, particularly gamma-band oscillations, which are closely associated with executive-control deficits. This study intends to validate the effect of HI-tACS treatment, which has been discovered in the previous pilot study. A three-month follow-up assessment will be conducted to test the changes in executive-control function and its underlying mechanism.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18-60, male or female, with 9 or more years of education, and able to complete questionnaire evaluation and behavioral tests; * Meet DSM-5 (Diagnostic and Statistical Manual of mental disorders，DSM) diagnostic criteria for gambling disorder; * Have gambled for at least one year (at least once a week); * Normal vision and hearing, or within the normal range after correction; * Agree to cooperate in the follow-up evaluation; * No metal implantation in the head, no history of nerve problems or head injury, and no skin sensitivity. Exclusion Criteria: * Have severe cognitive impairment, such as a history of head trauma, -cerebrovascular disease, epilepsy, etc.; * Have used drugs promoting cognitive function in the last 6 months; * Have impaired intelligence (Intelligence Quotient\<70); * Abuse or dependence of psychoactive substances (except nicotine) in the last 5 years.
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What it tests

  • HI-tACS
  • Sham stimulation
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Where

1 site
Shanghai Mental Health Center
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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