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A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllKivu Bioscience Inc.
NCT07229313 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a 2-part, first-in-human, open-label study to determine the safety and tolerability of KIVU-107, a PTK7-directed antibody-drug conjugate, in participants with locally advanced or metastatic solid tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female ≥18 years of age * No therapy of proven efficacy exists for the tumor * Pathologically or histologically documented diagnosis of advanced / metastatic solid tumor malignancy that is resistant to standard therapy or for which no standard therapy is available. * Adequate bone marrow, kidney, and liver function * Measurable disease using RECIST v1.1 * ECOG 0 or 1 * Life expectancy ≥ 3 months Exclusion Criteria: * Prior treatment with any ADC with topoisomerase 1 inhibitor payload * Any PTK7 - targeted therapy * Uncontrolled cardiovascular disease * Active Hepatitis B, Hepatitis C, or HIV infection * History of interstitial lung disease * Major surgery, radiation therapy, or systemic anti-cancer within 3 weeks of study treatment start.
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What it tests

  • KIVU-107
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Where

7 sites
Kivu Trial Site
Santa Monica, United States
Kivu Trial Site
New Have, United States
Kivu Trial Site
Camperdown, Australia
Kivu Trial Site
Sydney, Australia
Kivu Trial Site
Brisbane, Australia
Kivu Trial Site
Adelaide, Australia
Kivu Trial Site
Geelong, Australia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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