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Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy

RecruitingNAAges 18 Years - 65 YearsFemaleAtaturk University
NCT07232108 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to compare the effects of intrathecal morphine with trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response in patients undergoing elective laparoscopic hysterectomy. Laparoscopic hysterectomy is widely used for benign gynecologic conditions, but postoperative pain may result from trocar-site trauma, peritoneal irritation, and carbon dioxide insufflation. Effective postoperative analgesia can improve patient comfort, reduce opioid use, and enhance early recovery. Intrathecal morphine is known to provide potent early postoperative analgesia but may cause side effects such as nausea, vomiting, pruritus, and respiratory depression. Local anesthetic techniques, including trocar-site infiltration and intraperitoneal bupivacaine, have also been shown to reduce postoperative pain after minimally inva

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients aged 18-65 years. * Elective laparoscopic hysterectomy planned for benign gynecological conditions. * American Society of Anesthesiologists (ASA) physical status I-III. * Ability to provide written informed consent. Exclusion Criteria: * Coagulopathy or bleeding disorders. * Opioid dependence or chronic opioid use. * Allergy or contraindication to local anesthetics or morphine. * Contraindication to neuraxial (spinal) anesthesia. * History of chronic pain syndromes. * Severe renal or hepatic dysfunction. * Pregnancy or breastfeeding.
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What it tests

  • Intrathecal Morphine
  • Trocar-Site Bupivacaine Infiltration
  • Intraperitoneal Bupivacaine spray
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Where

1 site
Ataturk University
Erzurum, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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