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Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke

RecruitingNAAges 18 Years - anyAllUnidade Local de Saúde de Coimbra, EPE
NCT07232498 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability. In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients diagnosed with ischemic stroke aged 18 years or older; * Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours; * Informed consent obtained from the patient or legal representative. Exclusion Criteria: * Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4; * Diagnosis of Transient Ischemic Attack (TIA); * Severe hemodynamic instability, defined as: * Systolic blood pressure \< 100 mmHg or \> 220 mmHg; * Peripheral oxygen saturation \< 92%; * Heart rate \< 40 or \> 112 beats per minute; * Body temperature \> 38.5°C; * Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \< 10); * Patients who underwent neurosurgical intervention within the past 30 days; * Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer); * Requirement for continuous monitoring or continuous intravenous drug infusion; * Acute deep vein thrombosis/pulmonary embolism.
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What it tests

  • Doppler-guided early mobilization
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Where

7 sites
University Hospital Rijeka
Rijeka, Croatia
University Hospital Center Zagreb
Zagreb, Croatia
Unidade Local de Saude de Coimbra
Coimbra, Portugal
Unidade Local de Saúde de Santa Maria
Lisbon, Portugal
Unidade Local de Saude de Matosinhos
Porto, Portugal
Unidade Local de Saúde de São João
Porto, Portugal
ULS São José
Lisbon, Portugal
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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