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Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression

RecruitingNAAges 18 Years - 90 YearsAllPoznan University of Physical Education
NCT07232836 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Research Rationale and Study Design Lumbar spinal stenosis (LSS) is a common degenerative musculoskeletal disorder characterized by narrowing of the spinal canal, often leading to pain and disability. One of the primary contributors to this condition is hypertrophy (thickening) of the ligamentum flavum (LF), along with facet joint degeneration, intervertebral disc herniation, and ligament ossification. However, the pathophysiological mechanisms behind these changes remain incompletely understood. Histological changes in hypertrophied LF include fibrocartilaginous metaplasia, type II collagen proliferation, ossification, calcium crystal deposition, and degeneration of elastic and collagen fibers. Both mechanical stress and inflammatory processes, particularly macrophage infiltration, are considered key contributors to degeneration, especially in the aging population. Yet, inflammation li

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📋 Eligibility rules (as published)
Inclusion Criteria for the experimental group: 1. Spinal stenosis in the lumbar spine with a referral for surgical treatment using endoscopic spinal decompression. 2. Age: 40-90 years. 3. Current MRI results. 4. Consent to participate in the study. Inclusion Criteria for the control no spinal stenosis group: 1. Intervertebral disc herniation in the lumbar spine with a referral for surgical treatment using endoscopic discectomy. 2. Age: 18-40 years. 3. Current MRI results. 4. Consent to participate in the study. Exclusion Criteria: History of: * rheumatoid arthritis of the intervertebral joints, * joint pain located elsewhere if it is more severe than the pain caused by stenosis, * pathologies and/or medications that may disturb the balance between pro- and anti-inflammatory factors (e.g. inflammatory diseases, rheumatoid arthritis, ankylosing spondylitis, acute infection), * uncontrolled diabetes, poorly controlled hypertension, clinically significant liver function impairment, acute coronary event, unstable angina pectoris, symptoms of heart failure, pacemaker implantation, * neurological diseases within the last 6 months, * previous spine surgery at the lumbar level, * mechanical injuries to the spine after an accident, * advanced osteoporosis, * pregnancy, lactation.
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What it tests

  • Endoscopic Spinal Canal Decompression
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Where

1 site
Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi w Poznaniu
Poznan, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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