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Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation

Recruitingn/aAges 1 Month - 14 YearsAllHospital de Alta Complejidad en Red
NCT07233304 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric patients with acute respiratory distress syndrome (ARDS). These procedures are part of the standard care provided in the Pediatric Intensive Care Unit (PICU) and are used to improve pulmonary oxygenation and respiratory mechanics. Through this study, we aim to gather information that will help improve the safety and effectiveness of these interventions in critically ill patients.

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📋 Eligibility rules (as published)
Inclusion criteria: * Patients under 14 years of age admitted to the HCANK PICU * More than 4 hours of invasive mechanical ventilation (IMV) * An oxygenation index (OI) ≥4 or an oxygen saturation index (OSI) ≥5 * Indication for ARM and PEEP as determined by the treating team Exclusion criteria: * Predicted body weight (PBW) \>45.5 kg * Recent pulmonary resection surgery (\<7 days) * Presence of broncho-pleural fistula or peri-tube leak \>25% of the tidal volume * Hemoglobin decline \<7 g/dL * Patients with congenital or acquired heart diseases with significant intracardiac shunt.
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What it tests

  • Alveolar Opening Maneuver and PEEP Titration (AOM+P)
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Where

1 site
Hospital Cuenca Alta Néstor Kirchner
Canuelas, Argentina
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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