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Enteral Supplementation With Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules for the Treatment of Hypophosphatemia.

RecruitingNAAges 18 Years - 80 YearsAllUnion Hospital, Tongji Medical College, Huazhong …
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In plain words

What the trial is, and whether it could suit you

The purpose of this clinical trial is to evaluate the efficacy and safety of Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules for the treatment of participants with mild, moderate, and severe hypophosphatemia. The main questions it aims to answer are: Does enteral supplementation of Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules elevate participants' serum phosphorus? Does enteral supplementation of Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules cause gastrointestinal complications? Participants with hypophosphatemia will receive Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules orally or via nasogastric tube to observe the efficacy and safety of enteral phosphate supplementation. Participants will take Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules daily, with varying doses based o

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: 1. Aged 18-80 years (inclusive), regardless of gender; 2. ICU inpatients with a serum phosphate concentration \<0.80 mmol/L, and for whom the clinician determines phosphate supplementation is required; 3. Ability to receive enteral nutrition, with a daily enteral caloric intake ≥10 kcal/kg/day; 4. The subject or their legal guardian fully understands the purpose and significance of this trial, voluntarily agrees to participate, provides written informed consent, and is willing to strictly adhere to the clinical study protocol and complete the study. Exclusion Criteria: 1. Pregnant and lactating women; 2. Patients with contraindications for enteral administration, such as acute upper gastrointestinal bleeding, mechanical intestinal obstruction, severe acute pancreatitis, digestive tract fistula, gastrointestinal dysfunction, intra-abdominal hypertension, enteral feeding intolerance, or continuous gastrointestinal decompression; 3. Expected ICU stay ≤96 hours; 4. Known allergy to any component of the investigational drug or drugs with a similar chemical structure; 5. Severe renal impairment: estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m²; 6. Subjects with hyperthyroidism requiring clinical intervention; 7. Subjects requiring sodium restriction; 8. Other conditions deemed by the investigator as unsuitable for inclusion.
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What it tests

  • Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules
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Where

1 site
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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