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Interferon Reference for Older People - REFIPA Study

RecruitingNAAges 80 Years - anyAllHospices Civils de Lyon
NCT07239830 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The diagnosis of respiratory viral infections is mainly based on PCR tests targeting the DNA or RNA of suspected viruses, including SARS-CoV-2, RSV and influenza viruses. However, this method is limited because it only tests for a small number of viruses, while many other pathogens can cause similar symptoms. As a result, respiratory viral infections are often underdiagnosed because not all possible viruses are systematically tested for. Another limitation of PCR tests is that they can detect residual viral genetic material long after the infection has ended, making it difficult to distinguish between an active infection and a past one. Viral load can help interpret the result, but it is not always reliable. It is therefore essential to have complementary markers that can indicate whether the detected virus is still in the active replication phase. An innovative approach is to measure

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📋 Eligibility rules (as published)
Inclusion Criteria: * Subject aged 80 or over * Patient admitted to the Charpennes hospital day unit or outpatient clinic for follow-up OR accompanying patient who receive care at the Charpennes geriatric hospital OR subject recruited through the local press * Weight greater than or equal to 45 kg * Subject living in the Lyon metropolitan area Exclusion Criteria: * Subjects with symptoms of active infection (symptom questionnaire or temperature \> 37.5°C). * Subjects with an autoimmune disease linked to a dysregulated interferon response. * Subjects participating in another interventional study involving an exclusion period that is still ongoing or that may interfere with the present protocol. * Subjects deprived of their liberty by judicial or administrative decision * Subjects receiving psychiatric care * Adults subject to legal protection measures (guardianship, curatorship) * Subjects not affiliated with a social security scheme or beneficiaries of a similar scheme
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What it tests

  • Uninfected older adults
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Where

1 site
Hôpital des Charpennes (Hospices Civils de Lyon)
Villeurbanne, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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