💬In plain words
What the trial is, and whether it could suit you
The objective of this study is to assess to what extent goat's milk is better tolerated than cow's milk among individuals who report being intolerant to cow's milk, and, if so, to understand the underlying factors. To achieve this, digestive discomfort sensations and postprandial kinetics of nutrients after ingestion of cow's or goat's milk will be compared in two populations: individuals intolerant to cow's milk but not to goat's milk, and individuals who show no symptoms of intolerance to either cow's or goat's milk. For this purpose, approaches based on stable isotope labeling of milk will be employed.
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Individuals who report being intolerant to cow milk but not to goat milk (one group) or tolerant to both cow milk and goat milk (another group)
* Good general health (WHO grade = 0)
* Affiliated with a social security scheme
* Free, informed, and express consent, in accordance with the public health code: 'No research mentioned in 2° of Article L. 1121-1 can be conducted on a person without their free, informed, and express consent.
Exclusion Criteria:
* Individuals under guardianship or curatorship
* Individuals under legal protection
* Any known food allergies
* Anemia: hemoglobin levels below 13 g/dL for men and 12 g/dL for women
* Pregnant women or those likely to be (based on a positive urine pregnancy test at the time of inclusion)
* Excessive alcohol consumption (\>2 drinks/day). Harmful alcohol consumption is assessed by the investigator at the time of inclusion.
* Hypertension, diabetes, digestive tract diseases (except for irritable bowel syndrome, IBS), liver or kidney diseases, severe heart disease. The presence of these conditions will be assessed by the investigator based on usual clinical criteria and the volunteers' declarations during inclusion. Hypertension: Significant arterial hypertension as determined by the investigator or systolic blood pressure greater than or equal to 140 mmHg and/or diastolic blood pressure greater than or equal to 90 mmHg on the day of inclusion. Diabetes: Type 1 or Type 2 diabetes or any fasting blood glucose level \> 1.25 g/l. Digestive tract disease: Gastrointestinal disorders deemed by the investigator as clinically significant (bleeding, vomiting, constipation/diarrhea grade \>1), any inflammatory bowel disease, acute gastroenteritis in the month preceding the intervention. Liver disease: Any significant liver disorder as determined by the investigator or any AST/ALT \> 2.5 times the upper normal limit.
* Elite athletes (\> 8 hours per week)
* Blood donation in the 3 months preceding the start of the study
* Participation in a clinical study in the 3 months preceding the study
* Lack of free, informed, and express consent
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