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Beta-lactam Plus Levofloxacin to Enhance Therapy in Streptococcal Septicemia

RecruitingPhase 4Ages 18 Years - anyAllMahidol University
NCT07240077 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A double-blind randomized controlled trial comparing beta-lactam plus levofloxacin versus beta-lactam monotherapy for the treatment of Streptococcal bacteremia

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adults age\>18 years 2. Blood culture positive for Streptococcus (\<72 hours before enrollment) * at least 1 bottle of S. pyogenes, S. agalactiae, S. pneumoniae, S. suis * at least 2 bottle of other Streptococci 3. Receiving or having plan of receiving beta-lactam therapy Exclusion Criteria: 1. Known allergy to beta-lactam or fluroquinolone antibiotics 2. Pregnancy or lactating mother 3. EKG with QT prolongation 4. Diagnosis of infective endocarditis
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What it tests

  • Beta-lactam monotherapy
  • Beta-lactam plus levofloxacin combination therapy
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Where

4 sites
Faculty of Medicine Siriraj Hospital
Bangkok, Thailand
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, Thailand
Maharaj Nakhon Ratchasima
Nakhon Ratchasima, Thailand
Ratchburi Hospital
Ratchaburi, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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