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โ† Trials
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Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation

RecruitingNAAges 18 Years - 60 YearsAllKafrelsheikh University
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In plain words

What the trial is, and whether it could suit you

This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predicta

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Adults aged 18 to 60 years. Medically healthy patients classified as ASA I. Presence of a single non-restorable tooth indicated for extraction in the posterior maxilla. Adequate oral hygiene, with plaque and bleeding indices both below 20%. Sufficient bone volume to allow socket preservation without requiring simultaneous augmentation. Patients willing to participate in the study and able to provide written informed consent. Ability to commit to follow-up visits for up to 6 months. Exclusion Criteria: Smokers or tobacco users of any form. Presence of uncontrolled systemic diseases (e.g., uncontrolled diabetes). Conditions affecting bone metabolism (e.g., osteoporosis, long-term corticosteroid therapy). Pregnant or lactating women. History of radiotherapy in the head and neck region. Active infection or suppuration at the extraction site. Immunocompromised patients or those on immunosuppressive therapy. Patients taking medications known to impair healing (e.g., bisphosphonates). Allergy or hypersensitivity to any study-related materials.
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What it tests

  • Demineralized Allogeneic Dentin Graft
  • Mineralized Allogeneic Dentin Graft
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Where

1 site
Faculty of Dentistry, Kafrelsheikh University
Kafr ash Shaykh, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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