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Bone Marrow Aspirate Versus Platelet-Rich Fibrin for the Treatment of Chronic Plantar Fasciitis

RecruitingNAAges 18 Years - 75 YearsAllFederal University of São Paulo
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In plain words

What the trial is, and whether it could suit you

This randomized, double-blind clinical trial aims to compare the clinical and imaging effects of autologous bone marrow aspirate versus platelet-rich fibrin injections in patients with chronic plantar fasciitis. The procedures are performed under ultrasound guidance to ensure precision and safety. The study evaluates pain reduction, foot function, and ultrasonographic changes in the plantar fascia at follow-up intervals.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 to 75 years. * Clinical diagnosis of chronic plantar fasciitis for more than 6 months, confirmed by ultrasonography (increased plantar fascia thickness and hypoechogenicity). * Persistent heel pain refractory to conventional conservative treatment (stretching, orthotics, physical therapy, or corticosteroid injections). * Visual Analog Scale (VAS) pain score ≥ 4 at baseline. * Ability and willingness to comply with study procedures and follow-up assessments. * Signed informed consent. Exclusion Criteria: * Previous foot or ankle surgery on the affected limb. * Acute trauma, infection, or ulceration in the region of the plantar fascia. * Systemic inflammatory diseases (e.g., rheumatoid arthritis, lupus, psoriatic arthritis). * Metabolic or endocrine disorders interfering with healing (e.g., diabetes mellitus with poor glycemic control, thyroid disorders). * Current use of systemic corticosteroids, immunosuppressants, or anticoagulants. * Active neoplasia or hematologic disorders. * Pregnancy or breastfeeding. * Peripheral vascular disease or neuropathy affecting the lower limbs. * Contraindications to local anesthesia or venipuncture.
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What it tests

  • Bone Marrow Aspirate Injection
  • Platelet-Rich Fibrin Injection
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Where

1 site
Federal University of São Paulo - Hospital São Paulo
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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