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Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study

Recruitingn/aAges 3 Years - 50 YearsAllMohammad H. Abu Arja
NCT07242963 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to create a biobank for patients diagnosed with Sonic Hedgehog Medulloblastoma at Baylor College of Medicine/Texas Children's Cancer Center. A biobank is a facility that stores and manages biological samples (such as blood, tissue, or DNA) from individuals, along with detailed health information, for use in medical research to study diseases and develop new treatments. The investigators are requesting participants' permission to add their information and samples to this biobank. Being in this research study is voluntary; it is the participant's choice. If the participant joins this study, they can still stop at any time. If the participant decides to participate, the investigators will review the participant's clinical medical records, demographics, treatment history, family history, and imaging. The investigators will also collect biological samples from t

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📋 Eligibility rules (as published)
Inclusion Criteria: For Groups 1 and 2, subjects are eligible to be included in the study only if all of the following criteria are met: * Age Patients must be ≥ 3 and ≤ 50 years of age at the time of initial diagnosis. * Diagnosis Participants must have a diagnosis of SHH medulloblastoma by histologic or molecular criteria at the time of original diagnosis or relapse. * Disease status The disease must be recurrent, refractory, or progressive following therapy, including radiotherapy and chemotherapy. * Available tumor tissue sample for U1 testing Participants must have available tumor tissue samples to be tested for the U1 mutation. For Group 3, biological parent(s) of a subject participating in Group 1 or 2 are eligible. Exclusion Criteria: Subjects not meeting the inclusion criteria will be excluded.
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What it tests

  • Not listed
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Where

2 sites
Baylor College of Medicine
Houston, United States
MD Anderson Cancer Center
Houston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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