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Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

RecruitingNAAges 18 Years - 29 YearsAllUniversity of Iowa
NCT07244809 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Greater exposure to ACEs are associated with greater increases in the risk of cardiovascular diseases and death. Our laboratory has previously observed that vascular function is disrupted in young adults with prior ACE exposure, even though these individuals appear to be healthy clinically (i.e., no classic clinical cardiovascular disease risk factors). There is a need to identify and understand the biological mechanisms underlying these vascular impairments to inform effective interventions to reduce cardiovascular risks the millions of individuals affected by ACEs. The body's response to stress is coordinated across various systems, all of which depend on energy supplied by mitochondria (often referred to as th

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18-29 years * ACE score \>=4 Exclusion Criteria: * Resting arterial blood pressure \>140/90 mmHg * BMI \<=17 or \>= 35 * Are on a weight-loss diet or involved in a formal weight-loss program or are not intentionally weight stable for 6 months (+/- 5 kg) prior to the study. * Cardiovascular or metabolic prescription drug use * Vasoactive antidepressant drug use (SSRIs and clonidine) * Current heavy alcohol use, as defined as binge drinking on 5 or more days in the last month, or consuming more than 7 (women) or 14 (men) drinks per week in the last month (per NIAAA definition) * Current or recent (within the last 6 mo.) illicit drug use disorder as indicated by a score of 3 or greater on the Drug Abuse Screening Test (DAST-10) * Current tobacco or nicotine use * Vaping * Regular vigorous (\>6 METs) aerobic exercise (\>4 bouts/week, \>30 min/bout) * dietary supplementation with antioxidants or habitual use of NSAIDs * Currently pregnant or breastfeeding
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What it tests

  • Mitoquinone mesylate (MitoQ)
  • Placebo
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Where

1 site
Integrative Laboratory of Applied Physiology and Lifestyle Medicine
Iowa City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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