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Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps

RecruitingNAAges 18 Years - 65 YearsAllTongji Hospital
NCT07245329 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is designed to evaluate whether the addition of nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery (ESS) provides superior control of nasal mucosa inflammation compared to full-house ESS alone in patients with nasal polyps. Thirty-two adult participants will be randomly assigned to undergo either full-house ESS only or full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The primary outcome will be assessed through changes in inflammatory cell profiles at 1, 3, and 6 months postoperatively. Secondary outcomes include inflammatory cytokine levels, symptom scores, endoscopic findings, polyp recurrence rates, and safety measures.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18-65 years * Diagnosed with CRSwNP according to EPOS criteria * Blood eosinophil count \> 0.3 × 10⁹/L Exclusion Criteria: * Pregnant or lactating women. * Cystic fibrosis * primary ciliary dyskinesia * fungal ball rhinosinusitis * systemic vasculitis or granulomatous disease * malignancy * immunodeficiency. * Subjects with an upper-respiratory-tract infection within the past 4 weeks. * Clinically significant metabolic, cardiovascular, immune, neurologic, hematologic, gastrointestinal, cerebrovascular, or respiratory disorders, or any condition that, in the investigator's opinion, could interfere with outcome assessment or compromise patient safety. * Currently participating in another clinical trial or having participated in one within 30 days, or staff directly involved in this study.
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What it tests

  • Nasopharyngeal Lymphoid Tissue Ablation
  • Full-House Endoscopic Sinus Surgery
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Where

1 site
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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