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Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares

RecruitingPhase 4Ages 18 Years - anyAllSunnybrook Health Sciences Centre
NCT07245732 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improv

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📋 Eligibility rules (as published)
Inclusion Criteria: * Rheumatologist verified RA diagnosis. * Patients are allowed to be on non-steroidal anti-inflammatory drugs (NSAIDs) prior to randomization, but the dosages must be stable for ≥2 weeks prior to randomization. * Patients must be on stable doses of conventional synthetic disease-modifying antirheumatic drugs (csDMARD)/targeted synthetic disease-modifying antirheumatic drugs (tsDMARD)/biologics (bDMARDs) for ≥8 weeks prior to randomization. Exclusion Criteria: * Allergies, intolerances or contraindications to systemic GCs or IM injections * Patients with active malignancy, are pregnant or breastfeeding. * Patients who have received systemic or intra-articular GC within 4-weeks of randomization.
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What it tests

  • Glucocorticoid (GC)
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Where

5 sites
Sunnybrook Health Sciences Centre
Toronto, Canada
St. Michael's Hospital
Toronto, Canada
Women's College Hospital
Toronto, Canada
Toronto Western Hospital
Toronto, Canada
Mount Sinai Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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