Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care

Inclusion Criteria: * Patient ≥ 18 years old * Known homozygous sickle cell disease SS, SC, S-beta+, or S-beta0 * Admitted in an intensive care unit * Clinical diagnosis of vaso-occlusive crisis and/or acute chest syndrome * Receiving PCA treatment with morphine * Patient's consent for study participation and/or from a relative if case of patient's incapacity * Affiliation to social protection Exclusion Criteria: * Patient previously included in the study during a previous stay * Injection of iodinated contrast medium outside the scope of the study within 24 hours prior to inclusion, or scheduled within 9 hours following the scheduled time of iohexol injection * Contraindication to iohexol: known or suspected immediate or delayed hypersensitivity, thyrotoxicosis. * Patient undergoing morphine treatment or substitution treatment such as methadone or buprenorphine prior to hospitalization (having received morphine or a derivative regardless of the route of administration in the week prior to hospitalization). * Chronic liver disease likely to interfere with morphine metabolism (cirrhosis ) * Any condition that contraindicates the use of morphine according to the summary of product characteristics * Patients under legal protection * Pregnant or breastfeeding women Exclusion criteria : * Need for extrarenal epuration within 24 hours of inclusion