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Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI

RecruitingNAAges 18 Years - anyAllTheodoros Schizodimos
NCT07248995 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke) * Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission Exclusion Criteria: * Severe chronic brain diseases * Brain tumor or central nervous system (CNS) infection * Severe chronic pulmonary or cardiovascular disease * Severe coagulopathy * Undergoing decompressive craniectomy * Lack of invasive neuromonitoring * Withdrawal of life-sustaining treatment * Poor acoustic window in ultrasound
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What it tests

  • Stepwise Positive End-Expiratory Pressure (PEEP) Increase Protocol
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Where

1 site
George Papanikolaou General Hospital
Thessaloniki, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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