🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression

RecruitingNAAges 18 Years - 65 YearsFemaleSt. Joseph's Healthcare Hamilton
NCT07250893 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, the investigators ask questions about participants' physical and mental health and take blood samples.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Adults 18 years old or older * At or above 18 on HAM-D, indicative of moderate-severe depressive symptoms * Any childhood (before 18 years old) adversity as indicated by scores on the CECA q and ACES q Exclusion Criteria: * Individuals who meet for PTSD diagnosis from a criterion A trauma occurring in adulthood without a history of ELA * Individuals experiencing active mania or psychosis * Individuals with an active substance use disorder * Individuals presenting with active suicide risk (plan, intention, means) indicative of a need for higher level care * Individuals in current psychotherapeutic treatment (defined as having engaged in consistent psychotherapy within the last 3 months)
💊

What it tests

  • Psychotherapy
📍

Where

1 site
St. Joseph's Healthcare Hamilton
Hamilton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy