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PRetreatment MRI for OCcult Liver Metastasis Assessment In Pancreatic Ductal adenocarcinoMa

Recruitingn/aAges 18 Years - anyAllAzienda Ospedaliera SS. Antonio e Biagio e Cesare…
NCT07252076 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pancreatic cancer has a low survival rate largely due to late diagnosis and undetected liver metastases. Computed tomography (CT), the standard diagnostic tool, often misses occult metastases that are later discovered during surgery. Recent studies suggest that magnetic resonance imaging (MRI), especially with diffusion-weighted imaging (DWI), can better detect very small liver metastases and help avoid unnecessary surgery. However, MRI is not yet widely used in routine practice due to limited evidence and its selective application. This study proposes incorporating contrast-enhanced MRI and DWI into the diagnostic workflow to improve diagnostic accuracy and guide more effective treatment decisions for patients with pancreatic cancer.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female patients over 18 years of age. * Patients with a new cytological or histological diagnosis of PDAC. * A CT scan demonstrating pancreatic disease and meeting the minimum criteria for the imaging assessment of pancreatic gland tumors (see section 4.6, study procedures). * An MRI performed no later than 3 weeks after the CT scan, also meeting the minimum radiological criteria (see section 4.6, study procedures). * No prior treatment for pancreatic disease. * Patients able to receive and understand the study information and to provide written informed consent duly signed by both the patient and the investigator. Exclusion Criteria: * Signs of metastatic disease on the initial CT scan (hepatic, pulmonary, distant lymph node, peritoneal carcinomatosis, or other organ involvement).
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What it tests

  • Contrast-enhanced MRI and DWI sequences
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Where

1 site
SC Chirurgia Generale
Alessandria, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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