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Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia

RecruitingNAAges 20 Years - 50 YearsMaleMst.Sumyara Khatun
NCT07252518 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if drug Pentoxifylline plus Coenzyme Q10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Pentoxifylline plus Coenzyme Q10. The main questions it aims to answer are: Does drug Pentoxifylline plus Coenzyme Q10 increase the motility of sperm in participants? What medical problems do participants have when taking drug Pentoxifylline plus Coenzyme Q10 ? Researchers will compare drug Pentoxifylline plus Coenzyme Q10 combination to Coenzyme Q10 alone to see if drug Pentoxifylline plus Coenzyme Q10 combination works better. Participants will: Experimental Group:Pentoxifylline 400mg twice dailyand Coenzyme Q10 100mg twice daily for 3 months. Comparator Group: Coenzyme Q10 100mg twice daily for 3 months Visit the clinic after three months of treatment for checkups and tests

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📋 Eligibility rules (as published)
Inclusion Criteria: * Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021. * Age 20-50 years. Exclusion Criteria: * Severe oligoasthenoteratozoospermia * Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery. * Antioxidants supplmentation in the last 3 months * Drug, alcohol or substance abuse, psycho-sexual abnormalities. * Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage Severe oligoasthenoteratozoospermia * Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery. * Antioxidants supplmentation in the last 3 months * Drug, alcohol or substance abuse, psycho-sexual abnormalities. * Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage
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What it tests

  • Coenzyme Q 10
  • Pentoxifylline 400 MG Oral Tablet
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Where

1 site
Bangladesh Medical University
Dhaka, Bangladesh
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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