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Effect of Mechanical Loading and Bone Loss on Motor Neuron Activity-H-Reflex Relationship

RecruitingNAAges 18 Years - 65 YearsFemaleIstanbul Physical Medicine Rehabilitation Trainin…
NCT07253493 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Weight-bearing exercises (e.g., running, jumping, whole-body vibration) are widely practiced due to their beneficial effects on bone development and their role in the prevention and treatment of osteoporosis. However, the underlying neuroregulatory mechanisms responsible for these positive effects have not yet been fully understood. Two main neuromodulatory mechanisms have been proposed in the literature: (i) spinal reflexes originating from muscle spindles (stretch reflex, tonic vibration reflex), and (ii) the bone myoregulation reflex (BMR) based on load-sensitive osteocytes. It is well established that increased voluntary contraction and the associated rise in background EMG activity, that is, motor neuron pool activity, enhance muscle spindle-based reflex responses (such as the H-reflex and tendon reflex). In contrast, it has been demonstrated that the H-reflex is suppressed during

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📋 Eligibility rules (as published)
Inclusion Criteria: * Being in the postmenopausal period * For the osteoporosis group: having femoral osteoporosis (femoral neck or total femur T-score ≤ -2.5) * For the control group: having no osteoporosis or osteopenia (femoral neck and total femur T-scores \> -1, and L1-L4 and L2-L4 T-scores \> -1) * Being a volunteer Exclusion Criteria: * Receiving osteoporosis treatment * Having a peripheral or central nervous system disorder (e.g., stroke, polyneuropathy, radiculopathy, entrapment neuropathy, etc.) * Having acquired or hereditary muscle diseases (myopathies) * Having active painful lower extremity pathologies (e.g., osteoarthritis, inflammatory joint diseases, etc.) * Having cardiac arrhythmias * Having a history of other metabolic bone diseases * Having skin lesions at the electrode placement sites on the lower extremities * Being older than 65 years
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What it tests

  • H-reflex
  • Bone myoregulation reflex
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Where

1 site
Istanbul Physical Medicine Rehabilitation Training & Research Hospital
Bahçelievler, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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