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EPIGUT: EPILEPSY AND GASTROINTESTINAL MICROBIOTA: UNDERSTANDING THERAPY RESPONSE

Recruitingn/aAges 2 Years - 79 YearsAllKarolinska Institutet
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn how the bacteria in the gut and mouth (called the microbiota) are linked to different types of epilepsy and how they may affect how well seizure medicines work. Researchers want to answer two main questions: Are certain types of epilepsy linked to changes in the gut or mouth microbiota? Do the bacteria in the gut change how seizure medicines work for each person? Epilepsy is a brain condition that causes seizures. Even though there are many medicines for epilepsy, some people still have seizures or side effects. Studies in animals show that gut bacteria can raise or lower the chance of seizures. Smaller studies in people suggest the same thing, but they have been limited in size and scope. In this study, researchers will collect biological samples from people who have newly diagnosed epilepsy and from people without epilepsy (called he

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients: Age 2-79 years, newly diagnosed with epilepsy, treatment-naive at time of enrollment * Controls: Age 2-79 years Exclusion Criteria: * Patients: already started ASM treatment (more then one dose), has used antibiotics or probiotics in the last three months, has a gastrointestinal diagnosis, has surgically removed parts of the GIT, obesity (BMI\>30), T2D, follows a strict exclusion diet, is pregnant or breastfeeding, has a gastrostomy, PEG or jejunostomy * Controls: previous epilepsy diagnosis or ASM treatment, has used antibiotics or probiotics in the last three months, has a gastrointestinal diagnosis, has surgically removed parts of the GIT, obesity (BMI\>30), T2D, follows a strict exclusion diet, is pregnant or breastfeeding, has a gastrostomy, PEG or jejunostomy
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What it tests

  • Not listed
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Where

6 sites
Drottning Silvias Barnsjukhus
Gothenburg, Sweden
Universitetssjukhuset i Linköping
Linköping, Sweden
Skånes universitetssjukhus
Lund, Sweden
Karolinska Universitetssjukhus
Stockholm, Sweden
Norrlands universitetssjukhus
Umeå, Sweden
Akademiska Sjukhuset
Uppsala, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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